Abstract
The effects of various derivatives of cystamine [bis(2-amino-ethyl)disulfide] and dithioerythritol ( erythro isomer of 2,3-dihydroxy-1,4-dithiolbutane, DTE) on platelet aggregation, in vitro, were studied. DTE, like its isomer dithiothreitol (DTT), exerts a dual effect on platelet aggregation. At concentrations above 1 mM, it aggregates platelets, whereas at 0.2 mM, it abolishes collagen, ADP- or arachidonic acid-induced aggregation. The products of DTT and DTE oxidation, the trans and cis isomers of 4,5-dihydroxy- o-dithiane were found to inhibit strongly collagen- or ADP-induced aggregation. Bis(2-acetamidoethyl)disulfide and cystamine dihydrochloride salt are also potent inhibitors of platelet aggregation induced by collagen or ADP. Cystamine (free base) exerts a slight inhibitory effect at high concentrations and all the other synthesized or commercially available derivatives examined for their effect on platelet aggregation were found to be inactive.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
