Abstract
The development of allergic reactivity and the effect of disodium cromoglycate (DSCG) on that development were studied in groups of actively sensitized guinea pigs using both ocular sensitivity and antigen-induced histamine release from chopped lung, as test systems. DSCG reduced the allergic reactivity of animals actively sensitized for less than 12 days. At 12 days, DSCG was either inactive or it increased the reactivity of the animals. Antisera raised in animals co-immunized with <i>Bordetella pertussis</i> organisms were found to have a mixture of both IgE-like and γ<sub>1</sub>-like homocytotropic antibody properties. Passive cutaneous anaphylaxis (PCA) mediated by the IgE-like antibody was maximal at 48 h, was sensitive to heat and mercaptoethanol and was inhibited by DSCG. PCA mediated by γ<sub>1</sub>-like antibody was maximal at 4 h, was heat-stable, insensitive to 2-mercaptoethanol and DSCG and was apparently inhibited by concurrent stimulation of the IgE-mediated pathway.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International archives of allergy and applied immunology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
