Effect of Direct Oral Anticoagulants Versus Warfarin on Patency in High-Risk Bypass Patients

Abstract

The use of warfarin for anticoagulation in thromboembolic disease has been the mainstay of treatment. Direct oral anticoagulants (DOACs) have shown to have equivalent anticoagulant effects, without increased bleeding risks or need for frequent monitoring. However, the role of DOACs remains unclear as an alternative to warfarin for high-risk peripheral artery disease (PAD) interventions. The purpose of this study is to evaluate the efficacy of DOACs compared to warfarin during the postoperative period in patients that underwent a high-risk lower extremity bypass (HRB).