Abstract
This study determined the effect of ATP encapsulated in lipid vesicles (ATP-v) on cardiomyocytes and rats against chemical hypoxia or anoxia. ATP-v was prepared by homogenization of lecithin and Mg-ATP. KCN was added to cardiomyocyte culture. In ATP-v group, the redox status, the systolic and diastolic velocities and the systolic shortening were higher; but the CK and LDH release rates were lower (Table 1A). In rat study, ATP-v or control solutions were ip prior to KCN iv (10mg/kg/hr). The survival time was longer and the fatal dose of KCN was higher with ATP-v than with LRS (Table 1B). In anoxia study, ATP-v or LRS was iv (15μl/sec) prior to a three minute anoxia. 70% of rats with ATP-v and 30% with LRS survived. The high energy phosphates of heart in ATP-v group were higher, and the tissue water content was lower (Table 2). Our study shows that ATP encapsulated in lipid vesicles could deliver energy into cells against hypoxic damage. and has the potential for treatment of patients with critical stress.Table: Chemical Hypoxia
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
