Abstract
In previous studies white retinal emboli have been observed during open heart surgery in patients who postoperatively developed neurological complications and in patients who failed to survive (Williams, 1973). In the present study similar white retinal emboli were experimentally produced in dogs undergoing total cardiopulmonary bypass and were shown to comprise blood platelets. Trypsin digest flat preparations of the retina showed multiple capillary occlusions, some having characteristics of denatured cellular material and fat, others resembling silicone grease in vessels. The incidence of experimentally produced emboli comprising blood platelets and other cellular material was significantly reduced by adding dipyridamole (Persantin-Boehringer Ingelheim) a substance which impairs aggregation and adhesiveness of platelets, to the perfusate.
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