Abstract
In previous studies we have shown that glycolysis is strongly inhibited in cultured calvaria cells treated with ethane-1-hydroxy-1, 1-diphosphonate (EHDP) or dichloromethanediphosphonate (Cl2MDP). This study shows that the energy charge of the adenylate pool, and the ATP and Pi content, were not changed by treatment with diphosphonates except for a slight decrease of ATP and Pi at 0.25 mM Cl2 MDP. The uptake of Pi was diminished by 50% and 20% in cells treated for 6 days with Cl2MDP or EHDP, respectively, but not when diphosphonates were present only during the uptake studies.
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