Abstract
ABSTRACT This report describes the effect of short-term administration of therapeutic amounts of diphenylhydantoin (Dilantin) on the adrenal cortical function in 8 normal adults. The integrity of the pituitary-adrenal axis was evaluated by measuring alterations in the urinary excretion of 17-hydroxycorticosteroids after oral administration of SU-4885 (Metopirone). Adrenal cortical responsiveness was assessed by determining the increase in plasma 17-hydroxycorticosteroid levels following intramuscular ACTH gel. These studies were performed before and during diphenylhydantoin administration. Before receiving diphenylhydantoin, all 8 subjects had a normal plasma 17-hydroxycorticosteroid response to intramuscular ACTH, and an increased urinary excretion of 17-hydroxycorticosteroids following the administration of SU-4885. While receiving diphenylhydantoin, the effect of ACTH was unaltered in all 8 subjects, whereas 7 subjects now manifested an abnormal response to SU-4885. In 3, this was characterized by a la...
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