Abstract
The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Dimethoate is widely used as a potent pesticide in many countries and has been shown to produce some adverse health effects. In the present study, we investigated the effect of dimethoate (an organophosphate insecticide) on the reproductive system and fertility of male rats and the possible mechanism underlining its action. Twenty four adult Wistar male rats were divided into 4 groups of 6 animals per group and force-fed with 0, 3.66, 5.50 and 11 mg kg-1 body weight of dimethoate for 90 days. At 80 days of treatment, each males was allows to mate with two primiparous cyclic females. The results showed a significant decrease (p
Highlights
We investigated the effect of dimethoate on the reproductive system and fertility of male rats and the possible mechanism underlining its action
The results showed a significant decrease (p
Ferdinand Ngoula et al / American Journal of Pharmacology and Toxicology 9 (1): 75-83, 2014 of organophosphate pesticides is the central and peripheral nervous systems and its is by inhibiting acetylcholonesterase, a biochemical event that result in accumulation of endogenous acetylcholine at the nerve endings (Sarkar and Maitra, 1990; Gore, 2001)
Summary
The extensive use of Dimethoate may pose a health hazard to animals and humans because of its Dimethoate (DM) [(0, 0-dimethyl-S (N-methyl- persistence in soil and crops (IPCS/WHO, 1996). The carbonyl methyl) phosphorodithioate)] is an residue of DM and its analog (omethoate) were found in organophosphate insecticide with numerous uses on many food stuffs including cow milk (Srivastava and field, agricultural crops and ornamentals (Hayes and Raizada, 1996). Developmental toxicity of dimethoate includes decreased number of implantations and live fetuses, incidences of resorptions and decreased fetal body weights (Farag et al, 2006). Reproductive toxicity of this pesticide on adult rodents of both sexes have been demonstrated. Irregularities of Estrous cycle and altered level of serum gonadotrophins have been reported in females (Kaur and Dhanju, 2005; Mahadevaswami and Kaliwal, 2002), while impairment of fertility, suppressed libido, semen quality deterioration, altered testosterone levels and testicular degeneration are few of the reports available in males (Farag et al, 2007; Sayim, 2007; Ngoula et al, 2007a; 2007b)
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