Abstract
Background: Di(2-ethylhexyl) phthalate (DEHP) is the most commonly used as a plasticizer for polyvinyl chloride (PVC), but recently, concern has arisen over the DEHP which may act as a reproductive toxicant to humans. On the other hand, ethanol is the most common supplement of beverages and foods, and so many persons ingest a large quantity of ethanol in daily life. However, interactions between ethanol and DEHP toxicity are not well known. Method: To investigate the effect of dilute ethanol ingestion on the DEHP induced testicular atrophy, rats were received a 1% (w/w) DEHP diet and 2.5 or 5% (v/v) ethanol water for 7 days. Result: The rats treated with DEHP-diet alone for 7 days were observed significant testicular weight loss. On the other hand, testicular weight loss was significantly suppressed in rats treated with DEHP diet and ethanol water. A significant negative correlation between relative testicular weight (as a percentage of body weight) and testicular MEHP concentration was found among rats treated with DEHP-free diet (Control) and DEHP diet alone. Most of the data plots for the DEHP diet plus ethanol water group were scattered above the regression line. Conclusion: These results suggest that dilute ethanol may be effective in preventing DEHP testicular atrophy. However, the mechanism of prevention is unknown and further research is needed.
Highlights
These results suggest that dilute ethanol may be effective in preventing Di(2-ethylhexyl) phthalate (DEHP) testicular atrophy
Di(2-ethylhexyl) phthalate (DEHP), one of the phthalate esters is the most commonly used as a plasticizer for polyvinyl chloride (PVC), but recently, concern has arisen over the DEHP which may act as a reproductive toxicant to humans [1,2,3,4,5,6,7,8]
A significant negative correlation between relative testicular weight and testicular mono (2-ethylhexyl) phthalate (MEHP) concentration was found among rats treated with DEHP-free diet (Control) and DEHP diet alone
Summary
Di(2-ethylhexyl) phthalate (DEHP), one of the phthalate esters is the most commonly used as a plasticizer for polyvinyl chloride (PVC), but recently, concern has arisen over the DEHP which may act as a reproductive toxicant to humans [1,2,3,4,5,6,7,8].Many studies have shown the toxic effects of DEHP on male reproductive organs in the rodents at growth stages [9,10,11,12,13,14,15,16,17,18,19]. Di(2-ethylhexyl) phthalate (DEHP), one of the phthalate esters is the most commonly used as a plasticizer for polyvinyl chloride (PVC), but recently, concern has arisen over the DEHP which may act as a reproductive toxicant to humans [1,2,3,4,5,6,7,8]. The pathogenesis of testicular atrophy by DEHP is yet unclear, this injury has been suggested to be due to oxidative stress induced by mono (2-ethylhexyl) phthalate (MEHP), a metabolite of DEHP [20]. The present study has investigated the effects of ethanol ingestion on the DEHP induced testicular injury in rats. Di(2-ethylhexyl) phthalate (DEHP) is the most commonly used as a plasticizer for polyvinyl chloride (PVC), but recently, concern has arisen over the DEHP which may act as a reproductive toxicant to humans. Interactions between ethanol and DEHP toxicity are not well known
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