Abstract
The effectiveness of diltiazem, a slow channel calcium blocker, ibuprofen, a nonselective inhibitor of prostanoid synthesis, and the selective inhibition of thromboxane A 2 with imidazole and UK-38,485 in retarding the development of right ventricular (RV) hypertrophy was assessed in a rat model of chronic hypoxic pulmonary hypertension. Both ibuprofen and diltiazem significantly reduced RV hypertrophy in the chronically hypoxic rat. In contrast, selective inhibition of thromboxane A 2 was ineffective in reducing RV hypertrophy. The beneficial effect of ibuprofen was unrelated to inhibition of thromboxane A 2. Furthermore, thromboxane A 2 did not appear to be involved in the development of RV hypertrophy in this experimental model of hypoxic pulmonary hypertension.
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