Abstract
DURING the past few years many investigators1have studied the physiologic and pathologic effects of the fluorophosphates. Of these, the diisopropyl derivative (DFP) has received most attention. It has been shown to be a powerful inhibitor of cholinesterase2and therefore has pronounced parasympathomimetic and nicotinic actions. It is much more potent than physostigmine in these respects. In the eye, DFP has been shown to produce prolonged and marked miosis, spasm of the ciliary muscle, false myopia and decrease in intraocular tension.3The ocular effects of DFP far outlast those produced by other known miotic agents. For example, miosis was found to last two days in the rabbit,4ten days to two months in the cat5and three to nine days3aand fourteen to twenty-seven days3bin man. The spasm of the ciliary muscle has been found to last three to seven days in
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