Abstract
Using a phase contrast microscope and electron microscope, the effect of DHSM on the cochlea of KK mouse was studied. DHSM 200mg per kg of body weight was administrated daily, into the peritoneal space for 21 days.Same number of dd-strain mice were served as the control. No pathological finding was observed in the cellular element of stria vascularis, but a micro-embolism of destructed cell element was formed in the capillary space of KK mouse, but not of dd-strain mouse.It was suspected that these findings may be the initial stage of the degenerative process in the stria vascularis of KK mouse, and further the vascular vulnerability of this animal for the DHSM ototoxicity.
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