Effect of Digoxin on Clinical Outcomes in Patients on Contemporary Heart Failure Therapy

Abstract

Background: Previous trials have shown that digoxin is beneficial in subjects with heart failure (HF). However, these studies were conducted before the incorporation of beta-blockers as standard therapy for HF. There are limited data on the effect of digoxin in HF patients on a contemporary regimen of renin-angiotensin axis inhibitors and beta-blockers. Methods: 347 patients with HF admissions and depressed LV ejection fraction (LVEF), fulfilling Framingham criteria at the VA Hospital from 2002 to 2004 were analyzed according to use of digoxin at discharge.