Abstract
Notopterygium franchetii is a herb used in traditional Chinese medicine, where it is known as qianghuo. Its bioactive qualities are influenced by the post-harvest processing methods used (such as drying). However, changes in chemical components according to the drying method are unknown. Fresh roots and rhizomes of N. franchetii were subjected to seven drying methods. Chromatography-mass spectrometry combined with targeted and untargeted analyses were used to investigate relationships between drying methods and chemical concentrations. According to targeted evaluations of the six main bioactive constituents, their total contents decreased significantly in all drying methods. Hierarchical clustering analysis of the drying methods and total metabolome detected 30 chemical constituents, for which heap maps were obtained. Hot air drying was the best processing method, producing the least chemical changes at the lowest cost, while shade drying caused the greatest chemical changes. In conclusion, the wide range of chemical changes in N. franchetii caused by drying was investigated. Such changes potentially affect the quality of herbal medicines.
Highlights
Drying is the most fundamental procedure in the post-harvest processing of Chinese herbal medicines, as it affects their bioactive constituents and economic value [1]
Quantification and qualification methods were established to evaluate the quality of Notopterygium franchetii (NF) subjected to different post-harvest processing methods
The optimal drying method was hot air drying due to its less chemical transformation and high efficacy, and it should be used for the standardization of NF
Summary
Drying is the most fundamental procedure in the post-harvest processing of Chinese herbal medicines, as it affects their bioactive constituents and economic value [1]. It is believed that the concentration of bioactive components accumulates in the pre-harvest period and decreases during the post-harvest drying process, which is of long duration and uses high temperatures [3]. Research into Chinese medicine drying methods aims to optimize the contents and types of bioactive constituents existing in the plant. Notopterygium franchetii (NF), family Umbelliferae, has been used as a traditional Chinese medicine for thousands of years. It is officially named qianghuo in the Chinese Pharmacopeia (2015 edition)
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