Effect of different nutritional support routes on liver function after hepatectomy in cirrhotic rats

Abstract

Objective To explore the effects of different nutritional support routes on liver function after hepatectomy in cirrhotic rats.Methods Six normal rats severed as normal group,and 30 rats with liver cirrhosis were randomly divided into pre-operation group(n=6),post-hepatectomy with jugular vein catheter 1 day group(n=6),post-operation parenteral nutrition(PN)5 days group(n=6),post-hepatectomy with gastrostomy 1 day group(n=6),and post-operation enteral nutrition(EN)5 days group(n=6).Liver functions,expression of albumin(ALB)mRNA in the liver tissue,expression of liver signal transducers and activators of transcription-3(STAT-3)and antigen Ki67(Ki67)protein were detected.Result Compared with the PN 5 days group,serum aspartate aminotransferase,alanine aminotransferase,and alkaline phosphatase levels were significantly lower(P＜0.05),serum ALB and insulin-like growth factor-1 were significantly higher(P＜0.05),expression of ALB mR-NA in the liver tissue was significantly higher(P＜0.05),and expressions of liver STAT-3 and Ki67 protein were significantly higher(P＜0.05)in the EN 5 days group.Conclusion Post-hepatectomy EN in cirrhotic rats can speed up liver function recovery,prevent cholestasis,and promote liver protein synthesis and liver regeneration. Key words: Liver cirrhosis; Hepatectomy; Parentend nutrition; Enteral nutrition