Abstract
Hypoglycemia can occur during hemodialysis in diabetic chronic renal failure patients when using a dialysate without glucose. With dialysis solutions with glucose 90 mg/dL or more, this is preventable, but diabetic patients could present higher intradialytic glycemias. We tested a dialytic fluid with a lower level of glucose trying to prevent both hypo and hyperglycemia in these patients. Twenty diabetic individuals from our hemodialysis unit were submitted to 3 sessions with dialysis solutions with two different glucose concentrations--55 mg/dL (Phase 55), and 90 mg/dL (Phase 90)--and a glucose-free one (Phase ZERO). Plasma glucose levels were measured at five moments during each session--before and at 30, 60, 90 and 240 min. Results under 70 mg/dL were considered as hypoglycemia. Three patients presented 6 episodes of hypoglycemia in Phase 55, but no patient presented any episode in Phase 90. In Phase ZERO, five patients presented 7 episodes. This dialysate with a low level of glucose (55 mg/dL) did not prevent hypoglycemia episodes during hemodialysis in diabetic patients, these occurrences being similar to that when using a dialysate without glucose. The use of a 90 mg/dL glucose dialysis solution did not induce higher intradialytic glycemia levels than the other dialysis solutions.
Highlights
Hypoglycemia can occur during hemodialysis in diabetic chronic renal failure patients when using a dialysate without glucose
Previous studies have reported that diabetic patients with chronic renal failure may have episodes of hypoglycemia (HG), usually asymptomatic, during hemodialysis sessions when dialysate without glucose is used.[1,2,3,4,5,6,7,8]
It was observed that a dialysate containing around 100 mg/ dl of glucose causes average intradialytic blood glucose level higher than a glucosefree dialysate;[6,14] a similar finding was noted when comparing a dialysis solution containing glucose 200 mg/dl and another containing 100 mg/dl of glucose.[3,15]
Summary
Hypoglycemia can occur during hemodialysis in diabetic chronic renal failure patients when using a dialysate without glucose. Previous studies have reported that diabetic patients with chronic renal failure may have episodes of hypoglycemia (HG), usually asymptomatic, during hemodialysis sessions when dialysate without glucose is used.[1,2,3,4,5,6,7,8] These events tend to recur often,[1,2,3,4,5,6] and this recurrence has been identified as a cause for the absence of symptoms.[9] these recurrences may expose such patients to the risk of progressive cognitive impairment.[3,9,10,11,12,13]. It is logical to assume that frequent episodes of hyperand/or hypoglycemia during dialysis may be associated with a high long-term morbidity in these individuals
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
