Abstract
Objective To analyze the effect of glucose on cAMP generation and insulin secretion in INS-1 cell.Method We detected the changes of cAMP and insulin in INS-1 cell at 30 min stimulation by glucose of different concentrations (2.8,7.5,15 mmol/L).Result cAMP generation and insulin secretion in INS-1 cell were obviously stimulated as glucose concentration increased (P ＜ 0.05) and were relative to the concentration of glucose.Conclusion The increasing concentration of glucose could induce the cAMP production and insulin secretion in INS-1 cell. Key words: Glucose; cAMP; ELISA; Second messengers; Insulin secretion
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