Abstract
To evaluate the role of anti-inflammatory and analgesicof Iraqi pumpkin seed oil. The oil seed (25-100 mg / kg) were investigated using various experimental models for analgesic and anti-inflammatory benefit. Acetic acid and thermal induced models of pain were used to examine the anti-nociceptive property. Though models of oedema induced by carragenin were used to evaluate anti-inflammation. Results were reported from these studies that the extract prepared from Iraqi pumpkin seeds possess potential anti-inflammatory and analgesic activity when compared with standard drug Diclofenac. Even though all the concentrations showed varying degree of inflammatory and analgesic activity, 100mg/kg bw showed better anti inflammatory and analgesic activity
Highlights
Inflammation is a natural defense mechanism t hat defends the host from infection an other thr eats
Several bioactive molecules are being intensively investigated because of these risks. alternative bioactive molecules are being intensively investigated. fatty acids are highlighted as important effectors and regulators molecules in the immuneinflammatory response )15( most new pharmaceutical products derived from medicinal plants. )21(
Antioxidant and antiinflammatory effects. [27].The pumpkin seed oil is dark green in color that contains a high quantity of free fatty contain fatty acids (FAs); recognize namely oleic, linoleic, and palmitic acids
Summary
Inflammation is a natural defense mechanism t hat defends the host from infection an other thr eats This involves interactions between variou s cell varieties and chemical mediators to resto re physiological condition.)30(.Such mediators included lipid- derived mediators, peptide mediators, enzymes and adherence molecules, depending upon the cell type and the source of the injurious stimulation [6, 16, 20]. Numerous studies(17(have highlighted the health characteristics of pumpkin seed oil against various diseases in recent years, as well as obesity, diabetes and cancer. It has antibacterial, antioxidant and antiinflammatory effects. The aim of this study is to ivestigation the role effects of Pumpkin seeds oil as palliation and inflammation in mice
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