Effect of different doses of estrogen combined with balloon uterine stent on prevention of re adhesion after hysteroscopic surgery for severe intrauterine adhesions

Abstract

Objective To investigate the preventive effect of different doses of estrogen combined with balloon uterine stent on re adhesion after hysteroscopic surgery for severe intrauterine adhesions. Methods A total of 63 patients with severe hysteroscopy were selected in the study and the balloon uterine stent was used. According to the dose of estrogen, the patients were divided into group A and group B. The 32 patients in group A began taking valerate on the first day after operation, 3 mg at a time, 3 times/d, ranged 3 months, at the next 10 days, progesterone capsule was added, 200 mg at a time, 1 times/d. In group B, on the first day after operation, 31 patients began taking estradiol valerate 2 mg at a time, 3 times/d, ranged 3 months, at the next 10 days, progesterone was added, 200 mg at a time, 1 time a days. The re adhesion and menstruation situations were observed. Results The incidence of re adhesion was 12.50% in group A, and the rate of endometrial improvement was 81.25%, which were 16.13% and 74.19% in group B, and the differences between the two groups were not significant (P>0.05). The improvement rate of menstruation after 3 months in group A was 87.50%, which was significantly higher than that (64.52%) in group B, and the difference was significant (P<0.05). There was no serious adverse reaction in the two groups. Conclusions The use of large dose of estrogen combined with balloon uterine stent can effectively prevent uterine adhesion after hysteroscopic surgery for severe uterine adhesion. It can obviously promote the improvement of menstruation and has high safety, which is worth popularizing. Key words: Balloon uterus stent; Estrogen; Severe uterine adhesion; Hysteroscopy