Abstract
Summary Sprague-Dawley rats were treated for 2 weeks with diets containing either 40% butter plus 5% cholesterol (B group), or 0.3% thiouracil (T group), or both butter-cholesterol and thiouracil (BT group). The activity of tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (UK) was evaluated in euglobulin fractions, and PA inhibitor (PAI) activity in citrated plasma. The t-PA activity was increased in the BT group, compared with controls, but unchanged in the other experimental groups. PAI activity was increased in all treatment groups, but more pronouncedly in the BT group. Euglobulin UK activity did not differ between groups when assayed spectrophotometrically, but showed a decrease on fibrin autography in the BT group after dextran sulphate precipitation. The correlation between plasma triglycerides (TGs) and fibrinolytic variables (t-PA, UK, PAI) was different in the various treatment groups, suggesting that not only the TG levels, but also the way of producing these levels was of importance.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
