Effect of different calcineurin inhibitors on AOPP and TAS after kidney transplantation

Abstract

Objectives Little is known about the influence of calcineurin inhibitors on advanced oxidation protein products (AOPP) and total antioxidant status (TAS) after renal transplantation. Design and methods AOPP and TAS were evaluated in transplanted patients on different calcineurin inhibitors. Thirty-five patients were treated with cyclosporine A (group A) and 33 with tacrolimus (group B). Results Over 6 months, the mean levels of AOPP in group A decreased from 205.9 ± 125.7 to 140.9 ± 78.9 µmol/L and TAS from 1.89 ± 0.30 to 1.75 ± 0.27 mmol/L. In group B, the mean levels of AOPP decreased from 196.5 ± 123.9 to 129.6 ± 63.8 µmol/L and TAS from 1.80 ± 0.39 to 1.78 ± 0.23 mmol/L. Conclusion No significant differences in AOPP and TAS were found with respect to treatment. The only exception was the higher mean concentration of AOPP at month 1 in group A ( p = 0.026).