Abstract
The present study aimed to explore the effects of different anesthetic methods on cellular immune function and prognosis of patients with ovarian cancer (OC) undergoing oophorectomy. A total of 167 patients who received general anesthesia (GA) treatment (GA group) and 154 patients who received combined general/epidural anesthesia (GEA) treatment (GEA group) were collected retrospectively. Each group selected 124 patients that met the inclusion and exclusion criteria for further study. ELISA and radioimmunoassay were employed to detect levels of IL-2, TNF-α, and CA-125. The rates of tumor-red cell rosette (RTRR), red cell immune complex rosette (RRICR), and red cell C3b receptor rosette (RRCR) were also measured. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were determined by hemodynamics. The levels of tumor necrosis factor-α (TNF-α) and interleukin (IL)-2 decreased at 1 h intraoperation (T2), but increased 24-h post surgery (T3). The levels of TNF-α and IL-2 were recovered faster in the GEA group than in the GA group. The GA group exhibited greater levels of CA-125 expression than in the GEA group. The levels of RTRR, RRICR, and RRCR; ratios of CD3+, CD4+, CD4+/CD8+, CD16+, and CD56+ at 30 min after anesthesia (T1), T2, T3 and 48 h after the operation (T4) and levels of SBP, DBP, and HR at T1, T2, and T3 displayed increased levels in the GEA group than in the GA group. At 72-h post surgery (T5), the 5-year survival rate significantly increased in the GEA group compared with the GA group. GEA to be more suitable than GA for surgery on OC patients.
Highlights
Ovarian cancer (OC), a gynecological cancer widely considered a primary gynecological malignancy with a 5-year survival rate of 25–35% [1,2]
There were no significant differences in the operative time, intraoperative blood loss, and hospitalization time of the general anesthesia (GA) and general/epidural anesthesia (GEA) groups (P>0.05)
Our study demonstrated that rates of tumor-red cell rosette (RTRR), rate of red cell immune complex rosette (RRICR), and red cell C3b receptor rosette (RRCR) were much higher in the GEA group than in the GA group
Summary
Ovarian cancer (OC), a gynecological cancer widely considered a primary gynecological malignancy with a 5-year survival rate of 25–35% [1,2]. OC is characterized by several nonspecific symptoms such as dyspepsia, abdominal discomfort including fullness, and bloating [4]. Surgery and chemotherapy are often selected for OC patients; it is estimated that 70–75% of all women suffering from OC will experience a recurrence [6]. Laparoscopy is considered to be a minimally invasive and cost-effective surgical procedure capable of reducing postoperative pain, urinary tract infection, and managing ovarian neoplasms [7]. The respective method of anesthesia selected is associated with the risk of surgery [8]. It is of great importance to evaluate the effects of different anesthetic methods on OC patients
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
