Abstract
As a result of dietary vitamin K deficiency, male Macaca mulatta monkeys had prolonged prothrombin times which reversed spontaneously or could be decreased sharply by the administration of small quantities of vitamin K4. This pattern of prolongation and spontaneous reversal was also observed when neomycin sulfate and oxytetracycline were administered. The feeding of irradiated beef diets caused prolongation of the prothrombin time of only one pre-adolescent monkey, although the irradiated beef diets did not contain sufficient vitamin K to maintain rats, even when coprophagy was permitted.
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