Abstract
The objective of this study was to determine the effects of dietary vanadium on small intestinal morphology of broilers by the methods of light microscopy (LM) and transmission electron microscopy (TEM). A total of 420 one-day-old avian broilers were divided into six groups (seven replicates in each group and ten broilers in each replicate) and fed on a control diet or the same diet supplemented with 5, 15, 30, 45 and 60 mg/kg vanadium in the form of ammonium metavanadate for 42 days. In comparison with those in the control group, the intestinal villus heights were decreased (P < 0.05 or P < 0.01) in the 30, 45 and 60 mg/kg groups, and crypt depths and villus height/crypt depth ratio were decreased in the 45 and 60 mg/kg groups. Ultrastructurally, the microvilli were apparently sparse and short, and the numbers of lysosomes were increased in abovementioned three intestines in the 45 and 60 mg/kg groups at 42 days of age. In conclusion, dietary vanadium in excess of 30 mg/kg could alter the villus height, crypt depth, villus height/crypt depth ratio and ultrastructure, which might impact the development of small intestines in broilers.
Highlights
Vanadium as a “slightly” toxic has been ratified to be an essential trace element with anti-diabetic and anticarcinogenic properties during the last few decades [1]
Our previous researches have focused on the effect of vanadium in diets on the population of T cells, the content of cytokines and oxidative stress in small intestine [14,15,16], while the effect of dietary vanadium on small intestinal morphology has been rarely reported at present
The objective of this study was to determine the effect of dietary vanadium on intestinal morphology in broilers by the methods of light microscopy (LM) and transmission electron microscopy (TEM), and provided the systematic data about the influences of dietary vanadium on the morphology of small intestines in broilers, and helpful information for the same or similar studies in both human and other animals in the future
Summary
Vanadium as a “slightly” toxic has been ratified to be an essential trace element with anti-diabetic and anticarcinogenic properties during the last few decades [1]. Vanadium is a potent inhibitor of several phosphohydrolases such as Na+K+-ATPase [6] and Ca2+-ATPase [7], an activator of adenyl cyclase [8] and a potent anti-carcinogenic agent [9]. There are some reports regarding the effects of vanadium on lymphoid organs, liver and kidney [10,11,12,13]. The objective of this study was to determine the effect of dietary vanadium on intestinal morphology in broilers by the methods of light microscopy (LM) and transmission electron microscopy (TEM), and provided the systematic data about the influences of dietary vanadium on the morphology of small intestines in broilers, and helpful information for the same or similar studies in both human and other animals in the future
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