Abstract
BackroundThe aim of the present study was to assess the effects of zinc or copper and polyphenolic compounds on the 8-isoprostaglandin F2α concentration in the serum and urine of rats with mammary cancer (adenocarcinoma) induced with 7,12-dimethylbenz[a]antracene. The research focused on the kinetics of alterations in urinary 8-isoPGF2α at the early stage of carcinogenesis as well as the influence of dietary factors on the process. The impact of selected compounds on the intensity of DMBA - induced carcinogenesis was also assessed.Result and conclusionsAdministration of DMBA, a compound that inducers mammary tumors in experimental animals, increased the serum and urinary 8-isoPGF2α levels in study rats. In the rat model, diet supplementation with zinc, combined with selected polyphenolic compounds (resveratrol or genistein) yielded a statistically significant decrease in the rat serum and urinary biomarker concentration with a simultaneously significant stimulation of carcinogenesis.The results indicate that there is an inverse correlation between the intensity of DMBA-induced carcinogenicity and the level of 8-isoPGF2α in urine and serum of rats.
Highlights
Breast cancer represents the most common neoplastic disease in females, accounting for up to one third of new diagnoses of women’s cancer in certain region of the world
The results of this study indicated that the amount of 8-isoPGF2a in serum and urines from rats treated with cancerogenic factor and receiving a standard diet was higher than in the control group receiving analogous diet but with no DMBA treatment, the differences were not statistically significant for the reason of high values of standard deviation (Figures 1, 2 and 3)
Administration of DMBA resulted in an increase of biomarkers indicating damage of DNA (8-hydroxy-2’deoxyguanosine), proteins and lipids (8-isoPGF2a) [13]
Summary
Breast cancer represents the most common neoplastic disease in females, accounting for up to one third of new diagnoses of women’s cancer in certain region of the world. The fundamental issue in breast cancer control is prevention, which depends on detection of the determinants of the disease, in terms of initiation and promotion. It is worth mentioning that despite numerous research conducted in different areas, currently there is no one ideal, specific biomarker of the early phase of cancer development, including breast cancer. F2-isoprostanes are the isomers of F-prostaglandin, produced by cyclooxygenase-independent free radical. Another problem is the influence of dietary factor on biomarkers and the mechanisms of the disease development process. Dietary intake of trace elements and polyphenols becomes an important factor in controlling oxidative stress and the pathologies that ensue [4,5,6,7,8]
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