Abstract
1. 1. Addition of purines (adenine and guanine) and pyrimidines (cytosine and thymine) to the nutrient medium affected the growth and development of Drosophila melanogaster. 2. 2. Adenine was detrimental to the metamorphosis of the flies and caused weight reduction in newly hatched flies. 3. 3. Addition of 0.23% of adenine per 100 g of the nutrient medium was sufficient to reduce by one-half the number of adult flies hatched (LD 50 = 0.23%). 4. 4. Adenine also changed purine-pyrimidine profiles in the larval and pupal stages, but had no effect on these profiles in adult flies.
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