Abstract
1. Dietary phospholipids activate the acetylcholinesterase in the rat brain and increase the substrate affinity of the enzyme. 2. Acetylcholinesterase from the control group animals shows negative cooperativity. 3. After oral administration of phospholipids the negative cooperativity is eliminated. 4. An oleate-rich diet affects the brain enzyme in the same way. 5. The phospholipid composition of the rat brain is changed by orally administered phospholipids or oleate. 6. Dietary phospholipids do not noticeably influence the individual phospholipid composition in the rat liver.
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