Effect of Dietary Lipids on Accumulation of Pentachlorobenzene

Abstract

The present experiments were conducted to examine the effect of dietary lipid on the accumulation of pentachlorobenzene (PECB). Male Sprague Dawley rats (4-week-old) were fed diets of 10% or 20% soybean oil, 10% lard, 10% olive oil or 10% fish oil either containing or not containing 50mg% PECB for 2 weeks.Significant reductions of accumulated PECB in perirenal and epididymal fats were observed in rats fed the fish oil diet, while the content in the liver was comparable with those in rats fed other lipid diets. Although fecal excretion of PECB was significantly higher in rats fed the olive oil diet than those in rats fed other diets, the amount was only 6.3% of the estimated daily dose. Induction of cytochrome P-450 by PECB in hepatic microsomes was not observed only in rats fed fish oil diet. On the other hand, triglyceride in the liver and the weight of adipose tissues decreased in rats fed the fish oil diet.The above results suggest that feeding of fish oil may reduce accumulation of fat-soluble xenobiotics in adipose tissues and the mechanism may be related to the metabolism of triglyceride rather than an induction of drug-metabolizing enzyme(s).