Abstract
Indole-3-carbinol (IC), a compound present in cabbage and other cruciferous vegetables, was fed for 3 wk to young male Sprague-Dawley rats at dietary levels of 50, 500, 5000 and 7500 ppm. Because lower body weights were recorded in the animals fed the two highest levels of IC, pair-fed control groups of rats were used in a second experiment. Increased relative liver weights with enhanced activities of hepatic aminopyrine- N-demethylase, p-nitroanisole O-demethylase and aryl hydrocarbon hydroxylase (AHH) accompanied by higher cytochrome P-450 levels were observed only in the rats fed the two highest levels of IC either ad lib. or in the paired-feeding study. AHH activity increased also in the kidney, with enhanced glucuronide excretion, in the rats fed either of the two highest levels of IC. Intestinal AHH exhibited a significant induction only as a result of the 7500-ppm treatment. The dose-response relationships differed among the tissues. The induction of tissue mixed-function oxidases by only extremely high dietary levels of IC supports the conclusion that this indole is not the specific vegetable constituent that induces these enzymes in rats fed Cruciferae.
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