Abstract
The effect of 200 ppm of dietary fluoride on magnesium calcinosis was studied in rats and dogs. Dogs fed diets containing 30 ppm Mg showed magnesium deficiency symptoms and mineralization of soft tissues. Addition of 200 ppm of fluoride to the diet prevented the development of gross aortic lesions and calcification of soft tissues but did not prevent the occurrence of other symptoms. The protective effect of fluoride did not appear to be mediated by the change in the level of serum Ca, Mg or P. In rats, dietary fluoride at 200 ppm had no protective effect on soft tissue calcification when they were fed 30 ppm Mg. Serum Mg of rats fed low Mg diet appeared to be decreased by fluoride feeding.
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