Abstract
1. 1. The effect of dietary essential fatty acid (EFA) deficiency on Ca 2+-ATPase activity of rat submandibular gland microsomal fraction was studied. 2. 2. The specific activity of Ca 2+-ATPase per milligram of microsomal protein was depressed about 35% in rats fed the EFA-deficient diet as compared with that in those fed the control diet. 3. 3. Lineweaver-Burk plots for Ca 2+-ATPase activity showed no significant differences in K m values for Ca 2+ and ATP, but the V max ., was decreased in the EFA-deficient rats. 4. 4. The above results suggest that depression of the Ca 2+-ATPase activity in rats fed the EFA-deficient diet is probably due to the decrease in the V max of the enzyme.
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