Effect of diet on pancreas damage induced by excess lysine

Abstract

To clarify the effects of different protein levels in the diet on the severity of lysine-induced pancreatitis, macroscopic and electron microscopic observations of the pancreas, and analysis of the enzymes in pancreaticobile juice and blood serum were performed. A large injection of lysine induced necrosis of pancreatic acinar cells in a wider area in 5%-casein diet group, than in 20%-casein diet group or 20%-soybean protein isolate (SPI) diet group. On the other hand, as a complication of pancreatitis, necrotic figures of the fatty tissues in the retroperitoneum and mesenterium were macroscopically observed more in 20%-casein group and 20%-SPI group, but were not found in 5%-casein group. In 24 hours after injection, secretion of pancreaticobile juice decreased in 5%-casein group, but was not changed in 20%-casein group and 20%-SPI group. The trypsin activity in pancreaticobile juice was extremely lowered on one and three days in 5%-casein group, but was significantly elevated on one day in 20%-casein and 20%-SPI groups. It is thus known that the pancreatitis caused in the low protein nutritional state is seirous in the degree of damage of the pancreas itself, but is low in the incidence of complications, while the pancreatitis occurring in the sufficient protein uptake state, regardless of the type of protein, is relatively light in the severity of damage of the pancreas itself, but is likely to induce complications.