Abstract

Effect of diazoxide, a benzothiadiazine derivative, on the blood pressure, excretion of Na+, K+, and Ca2+, and the levels of these electrolytes in serum, kidney, and aorta were studield in rats with deoxycorticosterone acetate (DOCA)‐induced hypertension in comcarison with rats treated with hydrochlorothiazide. After a lateral nephrectomy, 5 mg kg−1of DOCA was injected subcutaneously three times a week. Drinking water for the rats injected with DOCA contained 1% NaCl. Systolic blood pressure in the DOCA‐induced hypertensive rats became about 170 mmHg, with associated elevation of serum level of Na+7 weeks after the treatment, whereas that in the normotensive rats was about 100 mmHg. In the DOCA‐hypertensive rats, urinary output, and renal excretion of Na+and Ca2+increased, and aortic tissue level of Ca2+decreased as compared with those in the normotensive rats. After 7 weeks of the treatment, diazoxide (10 mg kg−1) or hydrochlorothiazide (10 mg kg−1) was injected intravenously. Diazoxide decreased the blood pressure in both DOCA‐hypertensive and normotensive rats, whereas hydrochlorothiazide decreased it only in the DOCA‐hypertensive rats. Diazoxide recovered the tissue aortic Ca2+level that had been decreased by hypertension to that in the normotensive rats. Diazoxide may improve Ca2+perturbation in the vascular smooth muscle due to DOCA‐induced hypertension.

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