Abstract
Exposure of restrained rats to cold caused a drop in rectal temperature by 3°C, attenuated membrane potential by ΔΨT, decreased the level of lipid peroxidation products, and increased the viscosity of membrane lipids in thymocytes. Although diazepam (5 mg/kg, 1 h prior to experiment) decreased ΔΨT and lipid viscosity under comfortable temperature, it prevented the cold-induced changes in these parameters. Incubation of intact rat thymocytes with diazepam (0.2 μg/ml) decreased ΔΨT, increased lipid viscosity, and did not change the intensity of lipid peroxidation. Possibilities are discussed to reduced with the help of diazepam the cold-related energy losses not only due to its effect on the central benzodiazepine receptors, but also due to changes in functional and structural parameters of the membranes caused by interaction with peripheral receptors.
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