Abstract
Background: The factor leading to low Vitamin B12 status in patients with diabetes mellitus (DM) is still controversial. Objectives: The main objective of this study was to explore DM-induced changes in selected biological markers of Vitamin B12 in rats. Materials and Methods: DM was induced in rats by intraperitoneal administration of streptozotocin at 60 mg/kg body weight. The localisation and ultrastructure of pepsinogen (PEP)-containing cells were investigated using immunohistochemistry and transmission electron microscopy. In addition, enzyme-linked immunoassay was used to determine the gastric and serum levels of Vitamin B12, intrinsic factor (IF) and PEP-1. Results: The number of PEP-1-immunopositive cell was significantly (P
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
