Effect of diabetes mellitus on treatment response in locally advanced carcinoma cervix patients

Abstract

Abstract Aim: To study the effect of type 2 diabetes mellitus (T2DM) on treatment response in locally advanced carcinoma cervix patients receiving chemo-radiotherapy. Materials and Methods: A retrospective study was done in locally advanced carcinoma cervix patients also affected with T2DM in the Indian population, and a sample was collected from 2016 to 2018. Results: On analysis, 8.2% of patients were found to have T2DM, 4.9% of patients were found to have T2DM and hypertension, 12.56% of patients were found to have hypertension, and 74.31% of patients had no comorbidity. Patients with diabetes and diabetes plus hypertension have 25% cases of residual and 37.5% cases of recurrence, whereas patients with no comorbidity, 14.7% have residual and 16.91% have recurrence. Conclusion: In this retrospective study, we found that patients of carcinoma cervix with diabetes mellitus and diabetes plus hypertension had poor responses to radiation resulting in more cases of residual and recurrences due to the multitude of effects of diabetes on the body. Hypertension alone did not affect the treatment response to radiation.