Abstract
BackgroundIncreasing evidences indicated that diabetes might increase the incidence of gallbladder cancer. However, no sufficient data has ever clarified the impact of diabetes on the survival of patients with gallbladder cancer.MethodsWe comprehensively searched PubMed, Embase, and the Cochrane Library databases through July 2019 in order to find sufficient eligible researches. The pooled hazard risks (HRs) and relative risks (RRs) with 95% confidence intervals (CIs) were calculated with either fix-effects or random-effects model. Due to the low gallbladder cancer mortality in general population, the RRs and standard mortality ratios (SMRs) were considered the similar estimates of the HRs.ResultsTen eligible studies were included in this meta-analysis. Analysis of eight cohorts found that diabetes was closely associated with the mortality of gallbladder cancer (HR = 1.10; 95% CI: 1.06–1.14; P < 0.00001). However, the mortality in male diabetes patients was not higher than female patients (RR = 1.08, 95%CI = 0.57–2.04, P = 0.80).ConclusionsThese findings indicated that diabetes patients had a higher mortality of gallbladder cancer compared with non-diabetes.
Highlights
Increasing evidences indicated that diabetes might increase the incidence of gallbladder cancer
Eight studies reported the relationship between Diabetes mellitus (DM) and gallbladder cancer mortality, while four studies assessed the different gallbladder cancer mortality in male and female DM patients
We merged the data of these studies and found that pre-existing diabetes had a high correlation with the mortality of gallbladder cancer compared with non-DM participants (HR = 1.10; 95% confidence intervals (CIs): 1.06–1.14; P < 0.00001; Fig. 4)
Summary
Increasing evidences indicated that diabetes might increase the incidence of gallbladder cancer. No sufficient data has ever clarified the impact of diabetes on the survival of patients with gallbladder cancer. Gallbladder cancer (GBC) is one of the most common biliary tract malignancies worldwide [1]. Poor prognosis seriously affects the mortality of patients with gallbladder cancer [2]. Gallbladder cancer patients survive the mean survival rate of 6 months and a 5-year survival rate of 5% [3]. Women are two to six times more likely to be attacked by gallbladder cancer [4]. Advancing age partly demonstrates the prevalence of gallbladder cancer [10]
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