Effect of dezocine combined with propofol on painless gastroscopy in patients with suspect gastric carcinoma.

Abstract

To evaluate the effect of dezocine combined with propofol on painless gastroscopy in patients with suspect gastric carcinoma. Forty-three patients with gastric carcinoma who have underwent painless gastroscopy were retrospectively analyzed. For the 43 patients, 21 patients received propofol 1 mg/kg for painless gastroscopy (control group) and other 22 cases received dezocine 20 µg/kg plus propofol 1 mg/kg for painless gastroscopy (experiment group). The vital indexes (heart rate [HR], respiratory rate [RR], mean arterial pressure [MAP], and SpO2%), side effects, and recovery time were recorded at the time point T1 (before dosing), T2 (disappearance of eyelash reflex), and T3 (recovery of orientation). The HR, RR, and MAP were significantly decreased in T2 compared to T1 in both experiment and control group (P < 0.05). However, the SpO2% was not changed at T1, T2, and T3 in both experiment and control groups (P > 0.05). The RR at T2 was 16.8 ± 2.1 (n/ min) and 14.2 ± 1.8 (n/min) for experiment and control groups, respectively, with statistical difference (P < 0.05). The incidence rate of respiratory depression and body movement was 0.0%, 27.3% for experiment and 23.8%, 47.6% for control group with statistical difference (P < 0.05). The recovery time was 3.6 ± 0.8 min and 1.8 ± 0.6 min for control and experiment group, respectively, which demonstrated experiment group is much shorter than that of control group with statistical difference (P < 0.05). However, nausea and vomiting rate was not statistically different between the experiment and control groups (P > 0.05). Dezocine combined with propofol on painless gastroscopy can reduce the respiratory depression and body movement without interference of hemodynamics.