Abstract
Objective To study the effects of dexmedetomidine in combination with ropivacaine in patients undergoing craniocerebral surgery and their efficiency on cognitive function and inflammatory response of patients. Methods 100 patients undergoing craniocerebral surgery in our hospital from November 2018 to September 2020 were randomly selected and divided into a control group and an experimental group by drawing lots, with 50 cases in each group. Patients in the control group received routine anesthesia, while those in the experimental group received 1 μg/kg of dexmedetomidine combined with 0.5% of ropivacaine for anesthesia to compare the anesthesia onset time, analgesic time, postoperative awake time, Social Disability Screening Schedule (SDSS) cognitive function score after waking, visual analogue scale (VAS) pain score, Ramsay sedation score, incidence of adverse reactions, postoperative inflammatory factor expression levels, and changes in heart rate, oxygen saturation, and blood pressure at T0, T1, T2, T3, and T4 between the two groups. Results The anesthesia onset time, SDSS cognitive function score after waking, VAS pain score, Ramsay sedation score, incidence of adverse reactions, and postoperative inflammatory factor expression levels in the experimental group were significantly lower than those in the control group (P < 0.05). The analgesic time and postoperative awake time in the experimental group were significantly longer than those in the control group, with statistical significance (P < 0.05). There were no statistically significant differences in the changes of heart rate, oxygen saturation, and blood pressure at T0, T1, T2, T3, and T4 between the two groups (P > 0.05). Conclusion Dexmedetomidine combined with ropivacaine has high application value in craniocerebral surgery.
Highlights
Craniocerebral surgery is a common clinical brain surgery, generally referring to craniotomy, skull repair, etc
The Social Disability Screening Schedule (SDSS) cognitive function score, visual analogue scale (VAS) pain score, and Ramsay sedation score were compared between the two groups after waking
Craniocerebral surgery is required for brain tumors, severe brain trauma, cranial deformation, encephalorrhagia, and other diseases, which is a common brain surgery, but with a high risk due to the special surgical sites [13,14,15]
Summary
Craniocerebral surgery is a common clinical brain surgery, generally referring to craniotomy, skull repair, etc This surgery is often required for aneurysm, cerebral hemorrhage, cerebral trauma, and stable circulation during the perioperative period. Dexmedetomidine has a significant effect on the central nervous system and decreases the blood flow in the brain and the requirement or needs for cerebral oxygen. It modifies memory and enhances cognitive ability effects like sedation, analgesic, and anxiolytics. Dexmedetomidine is shown to decrease catecholamine in the brain and improves the perfusion ability in the penumbra It is a common drug mainly applied in tracheal intubation general anesthesia, BioMed Research International
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