Abstract
Occlusion of the middle cerebral artery (MCA) in cats results in a drop in blood flow in the territory normally supplied by the MCA, demonstrable by the measurement of rCBF with 85Krypton or by angiography. As a consequence of tissue hypoxia a rise in lactate, in lactate/pyruvate ratio and a breakdown of CrP, ATP and the energy charge potential is found in the ischemic area. At the borderline zone a slight hyperemia, followed by a secondary depression in blood flow, was recorded, accompanied by comparable alterations in energy-rich phosphates and in L/P ratio. A significant increase in water content of the grey and white matter occured already after 30 or 120 min, respectively. The accumulation of edema fluid takes place in the absence of protein extravasation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.