Abstract
The effects of dexamethasone on urinary PGE 2 excretion (U PGE 2 V) were investigated in rabbits that had free or restricted access to water intake. Dexamethasone, administered by rate-controlled osmotic pumps, enhanced U PGE 2 V in relation with urinary flow (UV) and sodium excretion (U NaV), from 290.4 ± 36.5 to 473.4 ± 49.5 ng/day. Under conditions of water restriction, dexamethasone had no effect on UV and U NaV but reduced U PGE 2 V from 235.5 ± 19.1 to 182.6 ± 10.5 ng/day. It is concluded that: (i) the rise in U PGE 2 V observed with dexamethasone was secondary to augmented UV or U NaV and (ii) urinary PG might not reflect renal synthesis during states of altered urinary flow.
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