Abstract
PLC-'/1 and maps to the distal portion of mouse chromosome 2. Reverse • L0708 transcriptase PCR assay utilizing Cded specific primers demonstrate Cded mRNAs in liver, heart, and brain tissues, throughout mid-embryonic mouse gestation. Analysis of the Cded promoter region shows high GC-content, high ratio of CpG/GpC, multiple GC-boxes, an absent TATA box, as well as AP2, and HNF1 binding sites. These characteristics are also found in several genes important in the regulation of cell growth or DNA synthesis, such as transforming growth factor-131, c-Ha-ras, nerve growth factor and epidermal growth factor receptor. Conclusions: The structural details described here are significant because Cded, by tethering other proteins with its PH domain, could play a vital role in liver development, particularly by involving the signal transduction process in hepatocyte formation.
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