Effect of denosumab on the incidence of nonvertebral fractures in postmenopausal women at increased risk of fracture: A freedom study subanalysis (study sponsored by Amgen Inc)

Abstract

glucocorticoids. Five months later, the radiological examination revealed a consolidation delay with the onset of an irritation callus. Double photon bone densitometry (DXA) of both femurs was indicated with an Hologic equipment (QDR4). A global decrease of -5.7% between the healthy side and the fractured one was evidenced, immediately above the fracture site (R1) of 4.9%, at the level of the fracture site (R2) of -0.9% and below the fracture site (R3) of -4.0%. This finding suggested that there was an osteoblastic activity at the fracture site. Discussion: In this case we could be dealing with a very special subgroup of patients with specific features. It is thus necessary to conduct further research because the effect of mechanical load support in the femur cortex could be lost. Disclosure of Interest: None declared