Abstract
The conversion of 17α-hydroxypregnenolone-7α-H3 to urinary dehydroisoandrosterone (D), androsterone (A) and etiocholanolone (E) was measured in a normal male subject and found to be 0.90%. When the circulating pool of dehydroisoandrosterone was increased in the same subject by the oral ingestion of dehydroisoandrosterone, the conversion of 7α-hydroxypregnenolone to the 3 urinary 11-desoxy-17-ketosteroids was 0.99 %, thus indicating that the increased pool size had no significant effect on the total conversion although the individual conversions were somewhat altered. These data provide additional evidence to support the view that metastatic tissue in patients with adrenal carcinoma is responsible for the enhanced conversion of 17α-hydroxypregnenolone to the urinary 11-desoxy-17-ketosteroids observed in such subjects.
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