Effect of Dehydration in Late Pregnancy on Fetal Rat Growth and Fetal Brain RAS Receptor Expression

Abstract

To study the effect of maternal dehydration on fetal growth and fetal brain RAS development in late pregnancy. The dehydration model of the maternal mice during the late pregnancy was established. The experiment was divided into two groups: use blood-gas analyzer to detect the blood gas and electrolyte parameters of the mother and fetus, and use the osmometer to detect the plasma osmotic pressure; use LaserDoppler to detect the fetal brain surface blood flow; detect the levels of angiotensin II receptor protein and angiotensinogen in fetal brain. The dehydration of maternal mice during the late pregnancy can significantly reduce the dry and wet weights of fetus and fetal brain. The serum sodium, hematocrit (HCT) and plasma osmotic pressure of fetal rats increase, and there is a statistical difference compared with the control group; the fetal cerebral blood flow (CBF) of dehydration group is significantly lower than that of the control group. Dehydration in late pregnancy can significantly affect fetal rat growth and fetal brain RAS receptor expression.