Effect of dehydration, food deprivation, saline and adrenalectomy on microsomal (Na ++K +)-dependent ATPase in the salivary glands and intestinal mucosa

Abstract

1. 1. The effect of water deprivation, food deprivation, saline and adrenalectomy was studied on microsomal ATPase activity of the rat parotid and submaxillary glands and the mucosa of the small intestine and of the colon. 2. 2. Water deprivation caused a decrease of microsomal (Na ++K +)-dependent ATPase activity in the submaxillary gland. 3. 3. Food deprivation resulted in a selective reduction of microsomal (Na ++K +)-dependent ATPase activity from the parotid gland. Mg 2+-ATPase activity was enhanced in the small intestine and depressed in the large intestine. 4. 4. When 0.9% NaCl was used as drinking fluid (Na ++K +)-dependent ATPase was augmented in the parotid and reduced in the mucosa of the small and large intestine. 5. 5. No decrease in (Na ++K +)-dependent ATPase activity was found after adrenalectomy in either salivary gland or in the mucosa of the small intestine or colon.