Effect of degradation in polymer scaffolds on mechanical properties: Surface vs. bulk erosion

Abstract

Porous polymeric scaffolds are used in tissue engineering to maintain or replace damaged biological tissues. Once embedded in body, they are involved into different physical and biological processes, among which their degradation and dissolution of their material can be singled out as one of the most important ones. Degradation parameters depend mostly on the properties of both the material and surrounding native tissues, which can substantially alter the original mechanical parameters of the scaffolds. The aim of this study is to examine the change in the effective mechanical properties of functionally graded additively manufactured polylactide scaffolds with a linear porosity gradient and morphology based on triply periodic minimal surfaces during simultaneous degradation and compressive loading. Two main types of scaffold-degradation processes, bulk and surface erosions are simulated with two suggested modelling methods. The fundamental differences in the proposed approaches are identified and the influence of different types of scaffold morphology on the change in effective elastic properties is evaluated. The results of this study can be useful for design of optimal scaffolds taking into account the effect of the degradation process on their structural integrity.