Abstract

Deferoxamine (DFO) was administered during the first 2 hours of hemodialysis and aluminum (Al) kinetics was studied during the next dialysis in 24 hemodialysis patients. After DFO administration, plasma Al and ultrafiltrable fraction of plasma Al increased significantly, and a reduction of 37.4 % in plasma Al after dialysis was obtained. The results demonstrated that DFO administered at the beginning of dialysis was effective in enhancement of Al removal during the subsequent dialysis. In the treatment of Al intoxication in hemodialysis patients, an administration of DFO at the beginning of every other dialysis is recommended.

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