Abstract
Objective The purpose was to explore the clinical effect of Danqi Buxin decoction on chronic heart failure (CHF) with yang deficiency and its effect on cardiac function and life quality of patients. Methods 106 CHF patients with yang deficiency treated in Jinan Municipal Hospital of Traditional Chinese Medicine from February 2019 to February 2020 were selected as the research objects and divided into the treatment group and reference group according to the odd and even admission numbers, with 53 cases in each group. The reference group was treated with routine antiheart failure drugs, while the treatment group was additionally treated with Danqi Buxin decoction to compare the clinical effect and cardiac function changes between the two groups. Results The clinical effective rate in the treatment group was significantly higher than that in the reference group (P < 0.05). The TCM symptom scores at T1, T2, and T3 in the treatment group were significantly higher than those in the reference group (P < 0.05). After treatment, the LVEDV levels in both groups were significantly higher than those before treatment, while the BNP levels were significantly lower than those before treatment (P < 0.001). The LVEDV level in the treatment group after treatment was higher than that in the reference group, while the BNP level in the treatment group was significantly lower than that in the reference group (P < 0.001). The life quality scores in the treatment group after treatment were significantly higher than those in the reference group (P < 0.05). Conclusion Danqi Buxin decoction on the basis of conventional drugs can significantly improve the cardiac function and life quality of CHF patients with yang deficiency type. Its further research is helpful to establish a good treatment plan for CHF patients.
Highlights
Chronic heart failure (CHF) is a syndrome in which heart disease develops to the end stage due to various causes
To analyze the therapeutic effect of Danqi Buxin decoction on CHF with yang deficiency type, 106 CHF patients with yang deficiency treated in our hospital from February 2019 to February 2020 were selected as the research objects, summarized, and reported as follows
Inclusion Criteria. 1 e patients met the diagnostic criteria of CHF in Guidelines for Diagnosis and Treatment of Chronic Heart Failure [9], with the clinical manifestations such as edema of both lower limbs, exertional dyspnea, and fatigue; 2 the patient met the Traditional Chinese medicine (TCM) diagnostic criteria of yang deficiency type in Guidelines for the Clinical Research of Chinese Medicine New Drugs [10], including fatigue, shortness of breath, and edema, with subsymptoms such as abdominal distension, cold body, and cold limbs; 3 the cardiac function of the patients were grades II–IV according to New York Heart Association (NYHA) classification of cardiac function; and 4 this study was approved by the Ethics Committee of Jinan Municipal Hospital of Traditional Chinese Medicine, and all patients had signed the informed consent
Summary
Chronic heart failure (CHF) is a syndrome in which heart disease develops to the end stage due to various causes. Significant progress has been made in the treatment of heart failure, there are still many shortcomings, such as side effects caused by vasodilators or diuretics. Erefore, exploring safe and efficient treatment methods is of great significance to improve the life quality and prolong survival time of patients. TCM classifies CHF as heart impediment, palpitation edema, and other categories and believes that the disease is a heart qi insufficiency syndrome that occurs mainly in the heart but Evidence-Based Complementary and Alternative Medicine involves important organs such as the kidney, spleen, and lung [6, 7]. Erefore, in the treatment of CHF, especially for patients with heart yang deficiency, the basic principle should be activating blood, dissolving stasis, dredging collaterals, inducing diuresis, and supplementing qi to warm yang [8]. To analyze the therapeutic effect of Danqi Buxin decoction on CHF with yang deficiency type, 106 CHF patients with yang deficiency treated in our hospital from February 2019 to February 2020 were selected as the research objects, summarized, and reported as follows
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