Abstract
AbstractThe effect of d‐amphetamine on the uptake, spontaneous release and stimulation‐induced release of catecholamines (CA) in central and peripheral tissues was investigated in vitro. d‐Amphetamine was most potent to cause release of extragranularly located CA, taken up after pretreatment with reserpine and nialamide. In agreement with previous investigations, it is concluded that this effect is probably mainly responsible for the well‐known central stimulating action of the drug at low doses. About ten times higher concentration was needed to reduce uptake and retention of CA in tissues of untreated rats. At about the same concentration increase of the stimulation‐induced tritium overflow was obtained both from NA and DA nerve terminals. This increase might contribute to the CA depletion caused by high doses of d‐amphetamine in vivo. Spontaneous CA release from tissues of untreated rats was affected only at a high concentration.
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